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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ENO1
All Species:
9.09
Human Site:
S254
Identified Species:
15.38
UniProt:
P06733
Number Species:
13
Phosphosite Substitution
Charge Score:
0.54
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06733
NP_001419.1
434
47169
S254
A
A
S
E
F
F
R
S
G
K
Y
D
L
D
F
Chimpanzee
Pan troglodytes
XP_511294
434
46968
N254
A
A
S
E
F
Y
R
N
G
K
Y
D
L
D
F
Rhesus Macaque
Macaca mulatta
XP_001098883
434
47136
S254
A
A
S
E
F
F
R
S
G
K
Y
D
L
D
F
Dog
Lupus familis
XP_536606
434
47036
N254
A
A
S
E
F
Y
R
N
G
K
Y
D
L
D
F
Cat
Felis silvestris
Mouse
Mus musculus
P17182
434
47122
S254
A
A
S
E
F
Y
R
S
G
K
Y
D
L
D
F
Rat
Rattus norvegicus
P04764
434
47109
A254
A
A
S
E
F
Y
R
A
G
K
Y
D
L
D
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505468
461
50129
D254
A
A
S
E
F
Y
R
D
G
K
Y
D
L
D
F
Chicken
Gallus gallus
P51913
434
47286
D254
A
A
S
E
F
Y
R
D
G
K
Y
D
L
D
F
Frog
Xenopus laevis
P08734
434
47486
D254
A
A
S
E
F
Y
R
D
G
K
Y
D
L
D
F
Zebra Danio
Brachydanio rerio
NP_997887
432
47041
G254
A
A
S
E
F
Y
K
G
G
K
Y
D
L
D
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15007
500
54292
D321
A
A
S
E
F
Y
K
D
G
Q
Y
D
L
D
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q27527
434
46598
D254
A
A
S
E
F
F
K
D
G
K
Y
D
L
D
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P42895
446
48144
D260
A
A
S
E
F
Y
S
D
K
D
Q
T
Y
D
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P25696
444
47701
E259
A
A
S
E
F
Y
S
E
D
K
T
Y
D
L
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.4
99.7
83.8
N.A.
94.6
94.6
N.A.
87.1
92.8
87.7
89.8
N.A.
63.5
N.A.
75.1
N.A.
Protein Similarity:
100
91.2
100
91.7
N.A.
98.8
98.1
N.A.
90.8
96.3
94.2
95.3
N.A.
73
N.A.
87
N.A.
P-Site Identity:
100
86.6
100
86.6
N.A.
93.3
86.6
N.A.
86.6
86.6
86.6
80
N.A.
73.3
N.A.
86.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
93.3
93.3
N.A.
93.3
N.A.
93.3
N.A.
Percent
Protein Identity:
N.A.
69.9
N.A.
71.6
N.A.
N.A.
Protein Similarity:
N.A.
81.6
N.A.
82.8
N.A.
N.A.
P-Site Identity:
N.A.
40
N.A.
40
N.A.
N.A.
P-Site Similarity:
N.A.
46.6
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
100
100
0
0
0
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
43
8
8
0
86
8
93
0
% D
% Glu:
0
0
0
100
0
0
0
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
100
22
0
0
0
0
0
0
0
0
86
% F
% Gly:
0
0
0
0
0
0
0
8
86
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
22
0
8
86
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
86
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
15
0
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
65
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
100
0
0
0
15
22
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
79
0
0
0
0
86
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _